Building on the anticipation from horror fans, especially those who grew up with the original video games, Zach Cregger's Resident Evil has navigated its initial theatrical run with impressive numbers. As reported by Ecran Large, the film has quickly established itself as a commercial success, distinguishing itself from other recent horror adaptations, including the less-than-stellar Return to Silent Hill from earlier this year.

In its second weekend in North American cinemas, Resident Evil secured the second position, pulling in an estimated $23.3 million across more than 3,600 screens. While it was outpaced by a re-release of Avengers: Endgame, its performance followed a strong $60 million opening weekend. The film's 61% drop in attendance is noteworthy, outperforming several contemporary horror titles such as Evil Dead Burn (-65%), 28 Years Later (-67%), and 28 Years Later: The Temple of the Dead (-72%). It also showed more resilience than the previous live-action entry, Resident Evil: The Final Chapter (-65%), though it slightly trailed the original 2002 Resident Evil's second-weekend hold (-62%). Interestingly, it had a sharper drop than 2021's Resident Evil: Welcome to Raccoon City (-49%), but that film had a much weaker initial opening of only $5 million.

Globally, the film continues to thrive, adding approximately $27 million from 65 international territories during its second weekend. This brings its worldwide cumulative total to over $196 million. This figure already places Cregger's Resident Evil among the highest-grossing films in the franchise's history, without even adjusting for inflation.

The film's reported production budget stands between $75-80 million, excluding promotional costs, with a significant portion, $20 million, reportedly going to director and co-writer Zach Cregger. This budget makes it a more substantial investment than previous entries like Resident Evil: Welcome to Raccoon City ($25 million) and Resident Evil: The Final Chapter ($40 million), aligning more closely with other major genre productions such as Alien: Romulus ($80 million).

The true test of its ultimate box office potential still lies ahead, with crucial releases scheduled for Asia. The film is set to debut in China on October 5th and in Japan on October 9th. These markets have historically been very lucrative for the Resident Evil franchise, with Resident Evil: The Final Chapter earning substantial amounts in both territories, contributing significantly to its $312 million worldwide total. Given the current momentum, the studio is undoubtedly hoping for a similar surge, potentially allowing Cregger's Resident Evil to surpass The Final Chapter and claim the top spot as the franchise's highest-grossing film.